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Crystal structure of a putative thiaminase II (SE1693) from Staphylococcus epidermidis ATCC 12228 at 1.65 A resolution

Source organism: Staphylococcus epidermidis ATCC 12228
Biochemical function: thiaminase activity
Biological process: organic hydroxy compound metabolic process
Cellular component: cytosol

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EC 3.5.99.2: Aminopyrimidine aminohydrolase

Reaction catalysed:
4-amino-5-aminomethyl-2-methylpyrimidine + H(2)O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + ammonia
Systematic name:
4-amino-5-aminomethyl-2-methylpyrimidine aminohydrolase
Alternative Name(s):
  • TenA (gene name)
  • Thiaminase
  • Thiaminase II

GO terms

Sequence family

Pfam Protein family (Pfam)
PF03070
Domain description: TENA/THI-4/PQQC family
Occurring in:
  1. Aminopyrimidine aminohydrolase
The deposited structure of PDB entry 3no6 contains 4 copies of Pfam domain PF03070 (TENA/THI-4/PQQC family) in Aminopyrimidine aminohydrolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016084
Domain description: Haem oxygenase-like, multi-helical
Occurring in:
  1. Aminopyrimidine aminohydrolase
IPR027574
Domain description: Thiaminase II
Occurring in:
  1. Aminopyrimidine aminohydrolase
IPR004305
Domain description: Thiaminase-2/PQQC
Occurring in:
  1. Aminopyrimidine aminohydrolase

Structure domain

CATH CATH domain
1.20.910.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Heme Oxygenase; Chain A
Homology: Heme oxygenase-like
Occurring in:
  1. Aminopyrimidine aminohydrolase
The deposited structure of PDB entry 3no6 contains 4 copies of CATH domain 1.20.910.10 (Heme Oxygenase; Chain A) in Aminopyrimidine aminohydrolase. Showing 1 copy in chain A.

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