› 3o41

X-ray diffraction
1.95Å resolution

Crystal Structure of 101F Fab Bound to 15-mer Peptide Epitope

Released:
DOI: 10.2210/pdb3o41/pdb
PDB entry 3o41 coloured by chain, front view.
PDB entry 3o41 coloured by chain, side view.
PDB entry 3o41 coloured by chain, top view.
Source organisms:
Primary publication:
Structure of a major antigenic site on the respiratory syncytial virus fusion glycoprotein in complex with neutralizing antibody 101F.
McLellan JS, Chen M, Chang JS, Yang Y, Kim A, Graham BS, Kwong PD
J Virol 84 12236-44 (2010)
PMID: 20881049

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208921 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Mouse monoclonal antibody 101F Fab light chain Chains: B, L
Molecule details ›
Chains: B, L
Length: 218 amino acids
Theoretical weight: 24.06 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Mouse monoclonal antibody 101F Fab heavy chain Chains: A, H
Molecule details ›
Chains: A, H
Length: 220 amino acids
Theoretical weight: 23.7 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
Structure domains: Immunoglobulins
Fusion glycoprotein F1 Chains: C, P
Molecule details ›
Chains: C, P
Length: 17 amino acids
Theoretical weight: 1.65 KDa
Source organism: Human respiratory syncytial virus A
Expression system: Not provided
UniProt:
  • Canonical: P03420 (Residues: 423-436; Coverage: 3%)
Gene name: F

Ligands and Environments

1 bound ligand:
Ligand SO4 14 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P212121
Unit cell:
a: 79.899Å b: 92.985Å c: 141.221Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.18 0.178 0.217
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

13 review citations

Progress in understanding and controlling respiratory syncytial virus: still crazy after all these years.
Collins et al. (2011)
12 more

6 mentions without citation

Antibody Epitopes of Pneumovirus Fusion Proteins.
Huang et al. (2019)
5 more