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Crystal structure of monomeric KlHxk1 in crystal form IX (open state)

Source organism: Kluyveromyces lactis
Biochemical function: mannokinase activity
Biological process: glucose 6-phosphate metabolic process
Cellular component: cytosol

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EC 2.7.1.1: Hexokinase

Reaction catalysed:
ATP + D-hexose = ADP + D-hexose 6-phosphate
Systematic name:
ATP:D-hexose 6-phosphotransferase
Alternative Name(s):
  • ATP-dependent hexokinase
  • Glucose ATP phosphotransferase
  • Hexokinase (phosphorylating)
  • Hexokinase D
  • Hexokinase type I
  • Hexokinase type II
  • Hexokinase type III
  • Hexokinase type IV
  • Hexokinase type IV (glucokinase)
  • Hexokinase type IV glucokinase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF03727
Domain description: Hexokinase
Occurring in:
  1. Hexokinase
The deposited structure of PDB entry 3o80 contains 1 copy of Pfam domain PF03727 (Hexokinase) in Hexokinase. Showing 1 copy in chain A.

PF00349
Domain description: Hexokinase
Occurring in:
  1. Hexokinase
The deposited structure of PDB entry 3o80 contains 1 copy of Pfam domain PF00349 (Hexokinase) in Hexokinase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001312
Domain description: Hexokinase
Occurring in:
  1. Hexokinase
IPR043129
Domain description: ATPase, nucleotide binding domain
Occurring in:
  1. Hexokinase
IPR022673
Domain description: Hexokinase, C-terminal
Occurring in:
  1. Hexokinase
IPR019807
Domain description: Hexokinase, binding site
Occurring in:
  1. Hexokinase
IPR022672
Domain description: Hexokinase, N-terminal
Occurring in:
  1. Hexokinase

Structure domains

CATH CATH domains
3.40.367.20
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Hexokinase; domain 1
Homology: Hexokinase; domain 1
Occurring in:
  1. Hexokinase
The deposited structure of PDB entry 3o80 contains 1 copy of CATH domain 3.40.367.20 (Hexokinase; domain 1) in Hexokinase. Showing 1 copy in chain A.
3.30.420.40
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Nucleotidyltransferase; domain 5
Homology: Nucleotidyltransferase; domain 5
Occurring in:
  1. Hexokinase
The deposited structure of PDB entry 3o80 contains 1 copy of CATH domain 3.30.420.40 (Nucleotidyltransferase; domain 5) in Hexokinase. Showing 1 copy in chain A.
1.10.287.1250
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: Helix Hairpins
Occurring in:
  1. Hexokinase
The deposited structure of PDB entry 3o80 contains 1 copy of CATH domain 1.10.287.1250 (Helix Hairpins) in Hexokinase. Showing 1 copy in chain A.

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