› 3p2m

X-ray diffraction
2.8Å resolution

Crystal Structure of a Novel Esterase Rv0045c from Mycobacterium tuberculosis

Released:
DOI: 10.2210/pdb3p2m/pdb
PDB entry 3p2m coloured by chain, front view.
PDB entry 3p2m coloured by chain, side view.
PDB entry 3p2m coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Crystal structure of a novel esterase Rv0045c from Mycobacterium tuberculosis.
Zheng X, Guo J, Xu L, Li H, Zhang D, Zhang K, Sun F, Wen T, Liu S, Pang H
OpenAccess logo PLoS One 6 e20506 (2011)
PMID: 21637775

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159813 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
AB hydrolase-1 domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 330 amino acids
Theoretical weight: 35.54 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P71702 (Residues: 2-298; Coverage: 100%)
Gene name: MT0051
Sequence domains: Alpha/beta hydrolase family
Structure domains: alpha/beta hydrolase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P31
Unit cell:
a: 73.465Å b: 73.465Å c: 48.063Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.217 0.286
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Cytosolic lipid inclusions formed during infection by viral and bacterial pathogens.
Stehr et al. (2012)
7 other articles

6 mentions without citation

Microbial esterases and ester prodrugs: An unlikely marriage for combating antibiotic resistance.
Larsen et al. (2019)
5 more