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Crystal structure of active caspase-6 in complex with Ac-VEID-CHO inhibitor

Source organism: Homo sapiens
Biochemical function: cysteine-type peptidase activity
Biological process: proteolysis
Cellular component: not assigned

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EC 3.4.22.59: Caspase-6

Reaction catalysed:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Val-Glu-His-Asp-|-
Systematic name:
-
Alternative Name(s):
  • Apoptotic protease Mch-2
  • CASP-6
  • Mch2

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00656
Domain description: Caspase domain
Occurring in:
  1. Caspase-6 subunit p18
  2. Caspase-6 subunit p11
The deposited structure of PDB entry 3p4u contains 2 copies of Pfam domain PF00656 (Caspase domain) in Caspase-6 subunit p18. Showing 1 copy in chain A.
The deposited structure of PDB entry 3p4u contains 2 copies of Pfam domain PF00656 (Caspase domain) in Caspase-6 subunit p11. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR015917
Domain description: Peptidase C14A, caspase catalytic domain
Occurring in:
  1. Caspase-6 subunit p18
  2. Caspase-6 subunit p11
IPR011600
Domain description: Peptidase C14, caspase domain
Occurring in:
  1. Caspase-6 subunit p18
  2. Caspase-6 subunit p11
IPR029030
Domain description: Caspase-like domain superfamily
Occurring in:
  1. Caspase-6 subunit p18
  2. Caspase-6 subunit p11
IPR002138
Domain description: Peptidase C14, caspase non-catalytic subunit p10
Occurring in:
  1. Caspase-6 subunit p11
IPR033139
Domain description: Peptidase family C14A, cysteine active site
Occurring in:
  1. Caspase-6 subunit p18
IPR016129
Domain description: Peptidase family C14A, His active site
Occurring in:
  1. Caspase-6 subunit p18
IPR001309
Domain description: Peptidase C14, p20 domain
Occurring in:
  1. Caspase-6 subunit p18
IPR002398
Domain description: Peptidase C14 family
Occurring in:
  1. Caspase-6 subunit p18

Structure domains

CATH CATH domains
3.30.70.1470
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Caspase-like
Occurring in:
  1. Caspase-6 subunit p11
The deposited structure of PDB entry 3p4u contains 2 copies of CATH domain 3.30.70.1470 (Alpha-Beta Plaits) in Caspase-6 subunit p11. Showing 1 copy in chain B.
3.40.50.1460
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Rossmann fold
Occurring in:
  1. Caspase-6 subunit p18
The deposited structure of PDB entry 3p4u contains 2 copies of CATH domain 3.40.50.1460 (Rossmann fold) in Caspase-6 subunit p18. Showing 1 copy in chain A.

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