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Crystal structure of mouse mitochondrial aspartate aminotransferase, a newly identified kynurenine aminotransferase-IV

X-ray diffraction
2.4Å resolution
PDB entry 3pd6 coloured by chain, front view.
PDB entry 3pd6 coloured by chain, side view.
PDB entry 3pd6 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aspartate aminotransferase, mitochondrial
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Multimeric state: hetero dimer
Accessible surface area: 30340.35 Å2
Buried surface area: 8905.23 Å2
Dissociation area: 3,532.27 Å2
Dissociation energy (ΔGdiss): 35.88 kcal/mol
Dissociation entropy (TΔSdiss): 14.85 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138594
Assembly 2
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Assembly Name: Aspartate aminotransferase, mitochondrial
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Multimeric state: hetero dimer
Accessible surface area: 30278.14 Å2
Buried surface area: 8921.75 Å2
Dissociation area: 3,452.94 Å2
Dissociation energy (ΔGdiss): 31.23 kcal/mol
Dissociation entropy (TΔSdiss): 14.83 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-138594

Macromolecules

Aspartate aminotransferase, mitochondrial
Chains: A, C
Length: 401 amino acids
Theoretical weight: 44.64 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05202 (Residues: 30-430; Coverage: 93%)
Gene names: Got-2, Got2
Pfam: Aminotransferase class I and II
InterPro:
CATH:
Aspartate aminotransferase, mitochondrial in PDB entry 3pd6, assembly 1, front view.
Aspartate aminotransferase, mitochondrial in PDB entry 3pd6, assembly 1, side view.
Aspartate aminotransferase, mitochondrial in PDB entry 3pd6, assembly 1, top view.
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Aspartate aminotransferase, mitochondrial
Chains: B, D
Length: 401 amino acids
Theoretical weight: 44.87 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05202 (Residues: 30-430; Coverage: 93%)
Gene names: Got-2, Got2
Pfam: Aminotransferase class I and II
InterPro:
CATH:
Aspartate aminotransferase, mitochondrial in PDB entry 3pd6, assembly 1, front view.
Aspartate aminotransferase, mitochondrial in PDB entry 3pd6, assembly 1, side view.
Aspartate aminotransferase, mitochondrial in PDB entry 3pd6, assembly 1, top view.
Molecule details ›

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