› › Function and Biology

Thermotoga maritima DAH7P synthase in complex with inhibitor

Source organism: Thermotoga maritima
Biochemical function: aldehyde-lyase activity
Biological process: chorismate biosynthetic process
Cellular component: not assigned

Quick links

EC 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase

Reaction catalysed:
Phosphoenolpyruvate + D-erythrose 4-phosphate + H(2)O = 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate + phosphate
Systematic name:
Phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolyzing, 2-carboxy-2-oxoethyl-forming)
Alternative Name(s):
  • 2-dehydro-3-deoxy-phosphoheptonate aldolase
  • 2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase
  • 3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase
  • 3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase
  • 3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase
  • 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate
  • 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating)
  • 7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating)
  • D-erythrose-4-phosphate-lyase
  • D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating)
  • DAH7-P synthase
  • DAHP synthase
  • DHAP synthase
  • DS-Co
  • DS-Mn
  • Deoxy-D-arabino-heptulosonate-7-phosphate synthetase
  • KDPH synthase
  • KDPH synthetase
  • Phospho-2-dehydro-3-deoxyheptonate aldolase
  • Phospho-2-keto-3-deoxyheptanoate aldolase
  • Phospho-2-keto-3-deoxyheptonate aldolase
  • Phospho-2-keto-3-deoxyheptonic aldolase
  • Phospho-2-oxo-3-deoxyheptonate aldolase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00793
Domain description: DAHP synthetase I family
Occurring in:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase
The deposited structure of PDB entry 3pg9 contains 8 copies of Pfam domain PF00793 (DAHP synthetase I family) in Phospho-2-dehydro-3-deoxyheptonate aldolase. Showing 1 copy in chain A.

PF18152
Domain description: DAHP synthase ferredoxin-like domain
Occurring in:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase
The deposited structure of PDB entry 3pg9 contains 8 copies of Pfam domain PF18152 (DAHP synthase ferredoxin-like domain) in Phospho-2-dehydro-3-deoxyheptonate aldolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006218
Domain description: DAHP synthetase I/KDSA
Occurring in:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase
IPR006268
Domain description: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2
Occurring in:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase
IPR041071
Domain description: DAHP synthase ferredoxin-like domain
Occurring in:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase

Structure domains

CATH CATH domains
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase
The deposited structure of PDB entry 3pg9 contains 8 copies of CATH domain 3.20.20.70 (TIM Barrel) in Phospho-2-dehydro-3-deoxyheptonate aldolase. Showing 1 copy in chain A.
3.30.70.1140
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Phospho-2-dehydro-3-deoxyheptonate aldolase; domain 1
Occurring in:
  1. Phospho-2-dehydro-3-deoxyheptonate aldolase
The deposited structure of PDB entry 3pg9 contains 8 copies of CATH domain 3.30.70.1140 (Alpha-Beta Plaits) in Phospho-2-dehydro-3-deoxyheptonate aldolase. Showing 1 copy in chain A.

Quick links