› 3pm8

X-ray diffraction
2Å resolution

CAD domain of PFF0520w, Calcium dependent protein kinase

Released:
DOI: 10.2210/pdb3pm8/pdb
PDB entry 3pm8 coloured by chain, front view.
PDB entry 3pm8 coloured by chain, side view.
PDB entry 3pm8 coloured by chain, top view.
Source organism: Plasmodium falciparum K1
Entry authors: Wernimont AK, Hutchinson A, Lew J, Chamberlain K, MacKenzie F, Loppnau P, Cossar D, Crombet L, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Hui R, Amani M, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127548 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-dependent protein kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 197 amino acids
Theoretical weight: 22.62 KDa
Source organism: Plasmodium falciparum K1
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15865 (Residues: 335-513; Coverage: 35%)
Gene names: CDPK2, CPK2
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

3 bound ligands:
Ligand CA 6 x CA
Ligand NA 3 x NA
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ SUPERBRIGHT
Spacegroup: P1
Unit cell:
a: 47.019Å b: 51.378Å c: 51.639Å
α: 68.53° β: 65.75° γ: 64.49°
R-values:
R R work R free
0.2 0.199 0.225
Expression system: Escherichia coli BL21(DE3)

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