EC 2.7.7.7: DNA-directed DNA polymerase
Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
- DNA duplicase
- DNA nucleotidyltransferase
- DNA nucleotidyltransferase (DNA-directed)
- DNA polymerase
- DNA polymerase I
- DNA polymerase II
- DNA polymerase III
- DNA polymerase alpha
- DNA polymerase beta
- DNA polymerase gamma
- DNA replicase
- DNA-dependent DNA polymerase
- Deoxynucleate polymerase
- Deoxyribonucleate nucleotidyltransferase
- Deoxyribonucleic acid duplicase
- Deoxyribonucleic acid polymerase
- Deoxyribonucleic duplicase
- Deoxyribonucleic polymerase
- Deoxyribonucleic polymerase I
- Duplicase
- Klenow fragment
- Sequenase
- Taq DNA polymerase
- Taq Pol I
- Tca DNA polymerase
GO terms
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
3.30.70.370
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Alpha-Beta Plaits
Homology:
Alpha-Beta Plaits
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3po5</span> contains 1 copy of CATH domain <span class='highlight'>3.30.70.370 (Alpha-Beta Plaits)</span> in <span class='highlight'>DNA polymerase I, thermostable</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 3po5 contains 1 copy of CATH domain 3.30.70.370 (Alpha-Beta Plaits) in DNA polymerase I, thermostable. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3po5_1_A_CATH_3.30.70.370_image-200x200.png)
1.10.150.20
Class:
Mainly Alpha
Architecture:
Orthogonal Bundle
Topology:
DNA polymerase; domain 1
Homology:
5' to 3' exonuclease, C-terminal subdomain
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3po5</span> contains 1 copy of CATH domain <span class='highlight'>1.10.150.20 (DNA polymerase; domain 1)</span> in <span class='highlight'>DNA polymerase I, thermostable</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 3po5 contains 1 copy of CATH domain 1.10.150.20 (DNA polymerase; domain 1) in DNA polymerase I, thermostable. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3po5_1_A_CATH_1.10.150.20_image-200x200.png)
1.20.1060.10
Class:
Mainly Alpha
Architecture:
Up-down Bundle
Topology:
Taq DNA Polymerase; Chain T, domain 4
Homology:
Taq DNA Polymerase; Chain T, domain 4
Occurring in:
![The deposited structure of PDB entry <span class='highlight'>3po5</span> contains 1 copy of CATH domain <span class='highlight'>1.20.1060.10 (Taq DNA Polymerase; Chain T, domain 4)</span> in <span class='highlight'>DNA polymerase I, thermostable</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 3po5 contains 1 copy of CATH domain 1.20.1060.10 (Taq DNA Polymerase; Chain T, domain 4) in DNA polymerase I, thermostable. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3po5_1_A_CATH_1.20.1060.10_image-200x200.png)