› 3pqz

X-ray diffraction
2.41Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163893 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth factor receptor-bound protein 7 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 117 amino acids
Theoretical weight: 13.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14451 (Residues: 416-532; Coverage: 22%)
Gene name: GRB7
Sequence domains: SH2 domain
Structure domains: SH2 domain
cyclic peptide Chains: L, M
Molecule details ›
Chains: L, M
Length: 11 amino acids
Theoretical weight: 1.44 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand CCS 2 x CCS

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P21
Unit cell:
a: 52.66Å b: 79.11Å c: 54.69Å
α: 90° β: 104.4° γ: 90°
R-values:
R R work R free
0.24 0.238 0.277
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

2 review citations

Progress towards the development of SH2 domain inhibitors.
Kraskouskaya et al. (2013)
1 more

5 mentions without citation

Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Gunzburg et al. (2016)
4 more