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Structure of Complement C5 in Complex with CVF

Source organisms:
Biochemical function: endopeptidase inhibitor activity
Biological process: complement activation
Cellular component: extracellular space

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01759
Domain description: UNC-6/NTR/C345C module
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF01759 (UNC-6/NTR/C345C module) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF01759 (UNC-6/NTR/C345C module) in Cobra venom factor. Showing 1 copy in chain B.

PF07677
Domain description: A-macroglobulin receptor binding domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF07677 (A-macroglobulin receptor binding domain) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF07677 (A-macroglobulin receptor binding domain) in Cobra venom factor. Showing 1 copy in chain B.

PF07678
Domain description: A-macroglobulin TED domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF07678 (A-macroglobulin TED domain) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF07678 (A-macroglobulin TED domain) in Cobra venom factor. Showing 1 copy in chain B.

PF00207
Domain description: Alpha-2-macroglobulin family
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF00207 (Alpha-2-macroglobulin family) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF00207 (Alpha-2-macroglobulin family) in Cobra venom factor. Showing 1 copy in chain B.

PF01821
Domain description: Anaphylotoxin-like domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF01821 (Anaphylotoxin-like domain) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF01821 (Anaphylotoxin-like domain) in Cobra venom factor. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF07703
Domain description: Alpha-2-macroglobulin bait region domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF07703 (Alpha-2-macroglobulin bait region domain) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF07703 (Alpha-2-macroglobulin bait region domain) in Cobra venom factor. Showing 1 copy in chain B.

PF17789
Domain description: Macroglobulin domain MG4
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF17789 (Macroglobulin domain MG4) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF17789 (Macroglobulin domain MG4) in Cobra venom factor. Showing 1 copy in chain B.

PF17791
Domain description: Macroglobulin domain MG3
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF17791 (Macroglobulin domain MG3) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF17791 (Macroglobulin domain MG3) in Cobra venom factor. Showing 1 copy in chain B.

PF01835
Domain description: MG2 domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF01835 (MG2 domain) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF01835 (MG2 domain) in Cobra venom factor. Showing 1 copy in chain B.

PF17790
Domain description: Macroglobulin domain MG1
Occurring in:
  1. Complement C5
  2. Cobra venom factor
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF17790 (Macroglobulin domain MG1) in Complement C5. Showing 1 copy in chain A.
The deposited structure of PDB entry 3pvm contains 2 copies of Pfam domain PF17790 (Macroglobulin domain MG1) in Cobra venom factor. Showing 1 copy in chain B.

PF21308
Domain description: Complement component 3, CUB domain, second segment
Occurring in:
  1. Cobra venom factor

PF21406
Domain description: Complement component 3, CUB domain, first segment
Occurring in:
  1. Cobra venom factor

PF21309
Domain description: Complement component 5, CUB domain
Occurring in:
  1. Complement C5

InterPro InterPro annotations
IPR001840
Domain description: Anaphylatoxin, complement system domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR018933
Domain description: Netrin module, non-TIMP type
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR009048
Domain description: Alpha-macroglobulin, receptor-binding
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR036595
Domain description: Alpha-macroglobulin, receptor-binding domain superfamily
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR000020
Domain description: Anaphylatoxin/fibulin
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR011625
Domain description: Alpha-2-macroglobulin, bait region domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR008993
Domain description: Tissue inhibitor of metalloproteinases-like, OB-fold
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR001134
Domain description: Netrin domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR008930
Domain description: Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR011626
Domain description: Alpha-macroglobulin-like, TED domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR001599
Domain description: Alpha-2-macroglobulin
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR018081
Domain description: Anaphylatoxin, complement system
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR040839
Domain description: Macroglobulin domain MG4
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR041555
Domain description: Macroglobulin domain MG3
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR002890
Domain description: Macroglobulin domain
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR041425
Domain description: Complement C3/4/5, macroglobulin domain MG1
Occurring in:
  1. Complement C5
  2. Cobra venom factor
IPR035815
Domain description: Complement C3-like, NTR domain
Occurring in:
  1. Cobra venom factor
IPR019742
Domain description: Alpha-2-macroglobulin, conserved site
Occurring in:
  1. Cobra venom factor
IPR047565
Domain description: Alpha-macroglobulin-like, thiol-ester bond-forming region
Occurring in:
  1. Cobra venom factor

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