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Crystal structure of human dpp-iv in complex withsa-(+)- methyl2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl- 7-oxo-5h-pyrrolo[3,4-b]pyridin-6(7h)-yl)acetate

Source organism: Homo sapiens
Biochemical function: chemorepellent activity
Biological process: glucagon processing
Cellular component: anchoring junction

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EC 3.4.14.5: Dipeptidyl-peptidase IV

Reaction catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
Alternative Name(s):
  • Amino acyl-prolyl dipeptidyl aminopeptidase
  • DPP IV
  • DPP IV/CD26
  • Dipeptidyl aminopeptidase IV
  • Dipeptidyl peptidase IV
  • Dipeptidyl-aminopeptidase IV
  • Dipeptidyl-peptide hydrolase
  • Gly-Pro naphthylamidase
  • Glycoprotein GP110
  • Glycylproline aminopeptidase
  • Glycylprolyl aminopeptidase
  • Glycylprolyl dipeptidylaminopeptidase
  • Leukocyte antigen CD26
  • Lymphocyte antigen CD26
  • Pep X
  • Post-proline dipeptidyl aminopeptidase IV
  • Postproline dipeptidyl aminopeptidase IV
  • T cell triggering molecule Tp103
  • X-PDAP
  • X-prolyl dipeptidyl aminopeptidase
  • Xaa-Pro-dipeptidyl-aminopeptidase
  • Xaa-Pro-dipeptidylaminopeptidase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00326
Domain description: Prolyl oligopeptidase family
Occurring in:
  1. Dipeptidyl peptidase 4
The deposited structure of PDB entry 3q0t contains 2 copies of Pfam domain PF00326 (Prolyl oligopeptidase family) in Dipeptidyl peptidase 4. Showing 1 copy in chain A.

PF00930
Domain description: Dipeptidyl peptidase IV (DPP IV) N-terminal region
Occurring in:
  1. Dipeptidyl peptidase 4
The deposited structure of PDB entry 3q0t contains 2 copies of Pfam domain PF00930 (Dipeptidyl peptidase IV (DPP IV) N-terminal region) in Dipeptidyl peptidase 4. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR029058
Domain description: Alpha/Beta hydrolase fold
Occurring in:
  1. Dipeptidyl peptidase 4
IPR002471
Domain description: Peptidase S9, serine active site
Occurring in:
  1. Dipeptidyl peptidase 4
IPR001375
Domain description: Peptidase S9, prolyl oligopeptidase, catalytic domain
Occurring in:
  1. Dipeptidyl peptidase 4
IPR002469
Domain description: Dipeptidylpeptidase IV, N-terminal domain
Occurring in:
  1. Dipeptidyl peptidase 4

Structure domains

CATH CATH domains
3.40.50.1820
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: alpha/beta hydrolase
Occurring in:
  1. Dipeptidyl peptidase 4
The deposited structure of PDB entry 3q0t contains 2 copies of CATH domain 3.40.50.1820 (Rossmann fold) in Dipeptidyl peptidase 4. Showing 1 copy in chain A.
2.140.10.30
Class: Mainly Beta
Architecture: 8 Propeller
Topology: Methanol Dehydrogenase; Chain A
Homology: Dipeptidylpeptidase IV, N-terminal domain
Occurring in:
  1. Dipeptidyl peptidase 4
The deposited structure of PDB entry 3q0t contains 2 copies of CATH domain 2.140.10.30 (Methanol Dehydrogenase; Chain A) in Dipeptidyl peptidase 4. Showing 1 copy in chain A.

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