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Pantoate-beta-alanine ligase from Yersinia pestis in complex with pantoate.

Source organism: Yersinia pestis
Biochemical function: ligase activity
Biological process: pantothenate biosynthetic process
Cellular component: cytosol

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EC 6.3.2.1: Pantoate--beta-alanine ligase (AMP-forming)

Reaction catalysed:
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
Systematic name:
(R)-pantoate:beta-alanine ligase (AMP-forming)
Alternative Name(s):
  • D-pantoate:beta-alanine ligase (AMP-forming)
  • Pantoate-activating enzyme
  • Pantoic-activating enzyme
  • Pantothenate synthetase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF02569
Domain description: Pantoate-beta-alanine ligase
Occurring in:
  1. Pantothenate synthetase
The deposited structure of PDB entry 3q12 contains 4 copies of Pfam domain PF02569 (Pantoate-beta-alanine ligase) in Pantothenate synthetase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003721
Domain description: Pantoate-beta-alanine ligase
Occurring in:
  1. Pantothenate synthetase
IPR042176
Domain description: Pantoate-beta-alanine ligase, C-terminal domain
Occurring in:
  1. Pantothenate synthetase
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. Pantothenate synthetase

Structure domains

CATH CATH domains
3.30.1300.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Pantoate--beta-alanine Ligase; Chain: A,domain 2
Homology: Pantoate-beta-alanine ligase, C-terminal domain
Occurring in:
  1. Pantothenate synthetase
The deposited structure of PDB entry 3q12 contains 4 copies of CATH domain 3.30.1300.10 (Pantoate--beta-alanine Ligase; Chain: A,domain 2) in Pantothenate synthetase. Showing 1 copy in chain A.
3.40.50.620
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HUPs
Occurring in:
  1. Pantothenate synthetase
The deposited structure of PDB entry 3q12 contains 4 copies of CATH domain 3.40.50.620 (Rossmann fold) in Pantothenate synthetase. Showing 1 copy in chain A.

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