› 3q91

X-ray diffraction
2.7Å resolution

Crystal Structure of Human Uridine Diphosphate Glucose Pyrophosphatase (NUDT14)

Released:
DOI: 10.2210/pdb3q91/pdb
PDB entry 3q91 coloured by chain, front view.
PDB entry 3q91 coloured by chain, side view.
PDB entry 3q91 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tresaugues L, Siponen MI, Arrowsmith CH, Berglund H, Bountra C, Collins R, Edwards AM, Ekblad T, Flodin S, Flores A, Graslund S, Hammarstrom M, Johansson I, Karlberg T, Kol S, Kotenyova T, Kouznetsova E, Moche M, Nyman T, Persson C, Schuler H, Schutz P, Thorsell AG, Van Der Berg S, Wahlberg E, Weigelt J, Welin M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
UDP-sugar + H(2)O = UMP + alpha-D-aldose 1-phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-523124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uridine diphosphate glucose pyrophosphatase NUDT14 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 218 amino acids
Theoretical weight: 23.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95848 (Residues: 28-222; Coverage: 88%)
Gene names: NUDT14, UGPP
Structure domains: Nucleoside Triphosphate Pyrophosphohydrolase

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Unit cell:
a: 84.04Å b: 106.24Å c: 106.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.228 0.271
Expression system: Escherichia coli BL21(DE3)

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