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Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).

Newell EW, Ely LK, Kruse AC, Reay PA, Rodriguez SN, Lin AE, Kuhns MS, Garcia KC, Davis MM
J Immunol 186 5823-32 (2011)
Related entries: 3qiu, 3qiw, 3qjf, 3qjh

Cited: 58 times
EuropePMC logo PMID: 21490152

Abstract

T cells specific for the cytochrome c Ag are widely used to investigate many aspects of TCR specificity and interactions with peptide-MHC, but structural information has long been elusive. In this study, we present structures for the well-studied 2B4 TCR, as well as a naturally occurring variant of the 5c.c7 TCR, 226, which is cross-reactive with more than half of possible substitutions at all three TCR-sensitive residues on the peptide Ag. These structures alone and in complex with peptide-MHC ligands allow us to reassess many prior mutagenesis results. In addition, the structure of 226 bound to one peptide variant, p5E, shows major changes in the CDR3 contacts compared with wild-type, yet the TCR V-region contacts with MHC are conserved. These and other data illustrate the ability of TCRs to accommodate large variations in CDR3 structure and peptide contacts within the constraints of highly conserved TCR-MHC interactions.

Reviews - 3qib mentioned but not cited (6)

  1. Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes. Singh NK, Riley TP, Baker SCB, Borrman T, Weng Z, Baker BM. J Immunol 199 2203-2213 (2017)
  2. Conformational variation in structures of classical and non-classical MHCII proteins and functional implications. Painter CA, Stern LJ. Immunol Rev 250 144-157 (2012)
  3. Roles for major histocompatibility complex glycosylation in immune function. Ryan SO, Cobb BA. Semin Immunopathol 34 425-441 (2012)
  4. T cell receptor bias for MHC: co-evolution or co-receptors? Rangarajan S, Mariuzza RA. Cell Mol Life Sci 71 3059-3068 (2014)
  5. Coevolution of T-cell receptors with MHC and non-MHC ligands. Castro CD, Luoma AM, Adams EJ. Immunol Rev 267 30-55 (2015)
  6. The perception and response of T cells to a changing environment are based on the law of initial value. Huseby ES, Teixeiro E. Sci Signal 15 eabj9842 (2022)

Articles - 3qib mentioned but not cited (12)



Reviews citing this publication (8)

  1. T cell antigen receptor recognition of antigen-presenting molecules. Rossjohn J, Gras S, Miles JJ, Turner SJ, Godfrey DI, McCluskey J. Annu Rev Immunol 33 169-200 (2015)
  2. γδ T cells: first line of defense and beyond. Chien YH, Meyer C, Bonneville M. Annu Rev Immunol 32 121-155 (2014)
  3. Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire. Zarnitsyna VI, Evavold BD, Schoettle LN, Blattman JN, Antia R. Front Immunol 4 485 (2013)
  4. T cells and their eons-old obsession with MHC. Yin L, Scott-Browne J, Kappler JW, Gapin L, Marrack P. Immunol Rev 250 49-60 (2012)
  5. Piecing together the family portrait of TCR-CD3 complexes. Kuhns MS, Badgandi HB. Immunol Rev 250 120-143 (2012)
  6. Antiviral memory phenotype T cells in unexposed adults. Su LF, Davis MM. Immunol Rev 255 95-109 (2013)
  7. Leishmania spp. Proteome Data Sets: A Comprehensive Resource for Vaccine Development to Target Visceral Leishmaniasis. Aebischer T. Front Immunol 5 260 (2014)
  8. Factors Influencing Microbiota in Modulating Vaccine Immune Response: A Long Way to Go. Ponziani FR, Coppola G, Rio P, Caldarelli M, Borriello R, Gambassi G, Gasbarrini A, Cianci R. Vaccines (Basel) 11 1609 (2023)

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