› 3qnf

X-ray diffraction
3Å resolution

Crystal structure of the open state of human endoplasmic reticulum aminopeptidase 1 ERAP1

Released:
DOI: 10.2210/pdb3qnf/pdb
PDB entry 3qnf coloured by chain, front view.
PDB entry 3qnf coloured by chain, side view.
PDB entry 3qnf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Kochan G, Krojer T, Harvey D, Fischer R, Chen L, Vollmar M, von Delft F, Kavanagh KL, Brown MA, Bowness P, Wordsworth P, Kessler BM, Oppermann U
Proc Natl Acad Sci U S A 108 7745-50 (2011)
PMID: 21508329

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192727 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Endoplasmic reticulum aminopeptidase 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 954 amino acids
Theoretical weight: 109.07 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q9NZ08 (Residues: 1-941; Coverage: 100%)
Gene names: APPILS, ARTS1, ERAP1, KIAA0525, UNQ584/PRO1154
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN
Carbohydrate polymer
2 bound ligands:
Ligand ZN 3 x ZN
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 97.246Å b: 132.816Å c: 233.687Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.229 0.283
Expression system: Trichoplusia ni

Quick links

Citations

55 review citations

Genetics of ankylosing spondylitis--insights into pathogenesis.
Brown et al. (2016)
54 more

9 mentions without citation

M1 aminopeptidases as drug targets: broad applications or therapeutic niche?
Drinkwater et al. (2017)
8 more