Function and Biology

Crystal structure of a human cytochrome P450 2B6 (Y226H/K262R) in complex with the inhibitor 4-Benzylpyridine.

Source organism: Homo sapiens
Biochemical function: estrogen 2-hydroxylase activity
Biological process: ketone metabolic process
Cellular component: intracellular membrane-bounded organelle

Sequence family

Pfam Protein family (Pfam)
PF00067
Domain description: Cytochrome P450
Occurring in:
  1. Cytochrome P450 2B6
The deposited structure of PDB entry 3qoa contains 1 copy of Pfam domain PF00067 (Cytochrome P450) in Cytochrome P450 2B6. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002401
Domain description: Cytochrome P450, E-class, group I
Occurring in:
  1. Cytochrome P450 2B6
IPR001128
Domain description: Cytochrome P450
Occurring in:
  1. Cytochrome P450 2B6
IPR008068
Domain description: Cytochrome P450, E-class, group I, CYP2B-like
Occurring in:
  1. Cytochrome P450 2B6
IPR036396
Domain description: Cytochrome P450 superfamily
Occurring in:
  1. Cytochrome P450 2B6
IPR017972
Domain description: Cytochrome P450, conserved site
Occurring in:
  1. Cytochrome P450 2B6

Structure domain

CATH CATH domain
1.10.630.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Cytochrome p450
Homology: Cytochrome P450
Occurring in:
  1. Cytochrome P450 2B6
The deposited structure of PDB entry 3qoa contains 1 copy of CATH domain 1.10.630.10 (Cytochrome p450) in Cytochrome P450 2B6. Showing 1 copy in chain A.