Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
- not assigned
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153244 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fms-related tyrosine kinase 3 ligand
Molecule details ›
Chains: A, B, C, D
Length: 138 amino acids
Theoretical weight: 15.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: flt3 ligand
Length: 138 amino acids
Theoretical weight: 15.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P49771 (Residues: 27-160; Coverage: 64%)
Sequence domains: flt3 ligand
Receptor-type tyrosine-protein kinase FLT3
Molecule details ›
Chains: E, F, G, H
Length: 527 amino acids
Theoretical weight: 59.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Immunoglobulin domain
Length: 527 amino acids
Theoretical weight: 59.53 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: P36888 (Residues: 27-540; Coverage: 53%)
Sequence domains: Immunoglobulin domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE ID23-1
Spacegroup:
P21
Expression systems:
- Escherichia coli
- Homo sapiens
