› 3qu6

X-ray diffraction
2.3Å resolution

Crystal structure of IRF-3 DBD free form

Released:
DOI: 10.2210/pdb3qu6/pdb
PDB entry 3qu6 coloured by chain, front view.
PDB entry 3qu6 coloured by chain, side view.
PDB entry 3qu6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding.
De Ioannes P, Escalante CR, Aggarwal AK
OpenAccess logo Nucleic Acids Res 39 7300-7 (2011)
PMID: 21596780

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172049 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon regulatory factor 3 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 116 amino acids
Theoretical weight: 13.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14653 (Residues: 1-113; Coverage: 27%)
  • Best match: Q14653-5 (Residues: 1-55)
Gene name: IRF3
Sequence domains: Interferon regulatory factor transcription factor
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

3 bound ligands:
Ligand ZN 9 x ZN
Ligand CL 7 x CL
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: P3221
Unit cell:
a: 64.908Å b: 64.908Å c: 157.621Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.213 0.263
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Transcriptional and chromatin regulation in interferon and innate antiviral gene expression.
Au-Yeung et al. (2018)
6 other articles

4 mentions without citation

Direct Inhibition of IRF-Dependent Transcriptional Regulatory Mechanisms Associated With Disease.
Antonczyk et al. (2019)
3 more