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Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza virus B, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2

Source organisms:
Biochemical function: ubiquitin protein ligase binding
Biological process: protein localization to mitochondrion
Cellular component: cytosol

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GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Ubiquitin-like protein ISG15

PF02942
Domain description: Influenza B non-structural protein (NS1)
Occurring in:
  1. Non-structural protein 1

InterPro InterPro annotations
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Ubiquitin-like protein ISG15
IPR019956
Domain description: Ubiquitin domain
Occurring in:
  1. Ubiquitin-like protein ISG15
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Ubiquitin-like protein ISG15
IPR015496
Domain description: Ubiquilin
Occurring in:
  1. Ubiquitin-like protein ISG15
IPR009068
Domain description: uS15/NS1, RNA-binding domain superfamily
Occurring in:
  1. Non-structural protein 1
IPR004208
Domain description: Influenza non-structural protein (NS1)
Occurring in:
  1. Non-structural protein 1

Structure domains

CATH CATH domains
3.10.20.90
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Occurring in:
  1. Ubiquitin-like protein ISG15
1.10.287.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Helix Hairpins
Homology: S15/NS1, RNA-binding
Occurring in:
  1. Non-structural protein 1

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