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Crystal structure of cytidylate kinase (Cmk) from Mycobacterium abscessus

X-ray diffraction
2.2Å resolution
PDB entry 3r8c coloured by chain, front view.
PDB entry 3r8c coloured by chain, side view.
PDB entry 3r8c coloured by chain, top view.
Source organism: Mycobacteroides abscessus ATCC 19977
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Cytidylate kinase
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Multimeric state: homo dimer
Accessible surface area: 18775.25 Å2
Buried surface area: 1339.59 Å2
Dissociation area: 669.8 Å2
Dissociation energy (ΔGdiss): -1.04 kcal/mol
Dissociation entropy (TΔSdiss): 12.28 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-109332
Homo dimeric assembly 1 of PDB entry 3r8c coloured by chemically distinct molecules, front view.
Homo dimeric assembly 1 of PDB entry 3r8c coloured by chemically distinct molecules, side view.
Homo dimeric assembly 1 of PDB entry 3r8c coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 2
Symmetry : C2
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3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : quaternary structure geometry is similar to that of 3r20_3 (73% id)

Macromolecules

Cytidylate kinase
Chains: A, B
Length: 228 amino acids
Theoretical weight: 23.87 KDa
Source organism: Mycobacteroides abscessus ATCC 19977
Expression system: Escherichia coli
UniProt:
  • Canonical: B1MB31 (Residues: 2-223; Coverage: 100%)
Gene names: MAB_2371, cmk
Pfam: Cytidylate kinase
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
Cytidylate kinase in PDB entry 3r8c, assembly 1, front view.
Cytidylate kinase in PDB entry 3r8c, assembly 1, side view.
Cytidylate kinase in PDB entry 3r8c, assembly 1, top view.
PDBe-KB: UniProt Coverage View: B1MB31  
122820406080100120140160180200220
 
100200
UniProt
B1MB31
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Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Sequence conservation
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