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Structure of Pseudomonas aeruginosa transcriptional regulator PA2196

X-ray diffraction
2.4Å resolution
PDB entry 3rd3 coloured by chain, front view.
PDB entry 3rd3 coloured by chain, side view.
PDB entry 3rd3 coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: HTH tetR-type domain-containing protein
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Multimeric state: homo dimer
Accessible surface area: 16521.38 Å2
Buried surface area: 3479.6 Å2
Dissociation area: 1,739.8 Å2
Dissociation energy (ΔGdiss): 10.86 kcal/mol
Dissociation entropy (TΔSdiss): 12.88 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-191276
Homo dimeric assembly 1 of PDB entry 3rd3 coloured by chemically distinct molecules, front view.
Homo dimeric assembly 1 of PDB entry 3rd3 coloured by chemically distinct molecules, side view.
Homo dimeric assembly 1 of PDB entry 3rd3 coloured by chemically distinct molecules, top view.
    Assembly 1
Confidence : 98%
No. subunits : 2
Symmetry : C2
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3DComplex & QSbio predictionx
No. subunits : 2
Symmetry : C2
Evidence : Interface geometry is similar to that of 2zcn_1 (24% id)

Macromolecules

HTH tetR-type domain-containing protein
Chains: A, B
Length: 197 amino acids
Theoretical weight: 22.06 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9I1S1 (Residues: 1-194; Coverage: 100%)
Gene name: PA2196
Pfam:
InterPro:
CATH: Tetracycline Repressor, domain 2
HTH tetR-type domain-containing protein in PDB entry 3rd3, assembly 1, front view.
HTH tetR-type domain-containing protein in PDB entry 3rd3, assembly 1, side view.
HTH tetR-type domain-containing protein in PDB entry 3rd3, assembly 1, top view.
PDBe-KB: UniProt Coverage View: Q9I1S1  
119720406080100120140160180
 
50100150GSHMKTSYDDTRQHLLDTGYRIMAVKGFSGVGLNEILQSAGVPKGSFYHYFKSKEQFGQALLEDYFRVYLADMDQRFSAPGLNARERLMSYWQKWLDNACPPCDEQRCLVVKLSAEVADLSESMRITLRDGSDGIIERLVGCLGQGRDDGSLAPCDARHMASALYQLWLGASLLSKLHRSPGPLETAMQTTRSLLEI
UniProt
Q9I1S1
Chains
Domains
Secondary structure
Flexibility predictions
Early folding residue predictions
Interaction interfaces
Sequence conservation
Molecule details ›

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