› 3rff

X-ray diffraction
1.76Å resolution

Phosphopantetheine adenylyltransferase from Mycobacterium Tuberculosis (1.76 A resolution)

Released:
DOI: 10.2210/pdb3rff/pdb
PDB entry 3rff coloured by chain, front view.
PDB entry 3rff coloured by chain, side view.
PDB entry 3rff coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Three-Dimensional Structure of Phosphopantetheine Adenylyltransferase from Mycobacterium Tuberculosis in the Apo Form and in Complexes with Coenzyme A and D
Timofeev VI, Smirnova EA, Chupova LA, Esipov RS, Kuranova IP
Crystallography Reports 57 96- (2012)

Function and Biology Details

Reaction catalysed: 
ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161935 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphopantetheine adenylyltransferase Chain: A
Molecule details ›
Chain: A
Length: 157 amino acids
Theoretical weight: 17.16 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPA5 (Residues: 1-157; Coverage: 98%)
Gene names: MTCY349.22, Rv2965c, coaD, kdtB, u0002e
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: R32
Unit cell:
a: 98.678Å b: 98.678Å c: 113.855Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.177 0.175 0.224
Expression system: Escherichia coli

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