› 3rfm

X-ray diffraction
3.6Å resolution

Thermostabilised adenosine A2A receptor in complex with caffeine

Released:
DOI: 10.2210/pdb3rfm/pdb
PDB entry 3rfm coloured by chain, front view.
PDB entry 3rfm coloured by chain, side view.
PDB entry 3rfm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine.
Doré AS, Robertson N, Errey JC, Ng I, Hollenstein K, Tehan B, Hurrell E, Bennett K, Congreve M, Magnani F, Tate CG, Weir M, Marshall FH
Structure 19 1283-93 (2011)
PMID: 21885291

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151373 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine receptor A2a Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 36.48 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P29274 (Residues: 1-317; Coverage: 77%)
Gene names: ADORA2, ADORA2A
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

1 bound ligand:
Ligand CFF 1 x CFF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: I222
Unit cell:
a: 112.327Å b: 113.328Å c: 129.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.298 0.297 0.311
Expression system: Spodoptera frugiperda

Quick links

Citations

72 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
71 more

46 mentions without citation

Structure-function of the G protein-coupled receptor superfamily.
Katritch et al. (2013)
45 more