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Crystal Structure of Klebsiella pneumoniae HpxO complexed with FAD and uric acid

Source organism: Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Biochemical function: FAD-dependent urate hydroxylase activity
Biological process: urate catabolic process
Cellular component: not assigned

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EC 1.14.13.113: FAD-dependent urate hydroxylase

Reaction catalysed:
Urate + NADH + O(2) = 5-hydroxyisourate + NAD(+) + H(2)O
Systematic name:
Urate,NADH:oxygen oxidoreductase (5-hydroxyisourate forming)
Alternative Name(s):
  • FAD-dependent urate oxidase
  • HpxO enzyme
  • Urate hydroxylase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01494
Domain description: FAD binding domain
Occurring in:
  1. FAD-dependent urate hydroxylase
The deposited structure of PDB entry 3rp7 contains 1 copy of Pfam domain PF01494 (FAD binding domain) in FAD-dependent urate hydroxylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. FAD-dependent urate hydroxylase
IPR047712
Domain description: FAD-dependent urate hydroxylase
Occurring in:
  1. FAD-dependent urate hydroxylase
IPR002938
Domain description: FAD-binding domain
Occurring in:
  1. FAD-dependent urate hydroxylase

Structure domains

CATH CATH domains
3.30.9.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: D-Amino Acid Oxidase; Chain A, domain 2
Homology: D-Amino Acid Oxidase; Chain A, domain 2
Occurring in:
  1. FAD-dependent urate hydroxylase
The deposited structure of PDB entry 3rp7 contains 1 copy of CATH domain 3.30.9.30 (D-Amino Acid Oxidase; Chain A, domain 2) in FAD-dependent urate hydroxylase. Showing 1 copy in chain A.
3.50.50.60
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: FAD/NAD(P)-binding domain
Homology: FAD/NAD(P)-binding domain
Occurring in:
  1. FAD-dependent urate hydroxylase
The deposited structure of PDB entry 3rp7 contains 1 copy of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in FAD-dependent urate hydroxylase. Showing 1 copy in chain A.

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