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The crystal structure of sucrose synthase-1 from Arabidopsis thaliana and its functional implications.

Source organism: Arabidopsis thaliana
Biochemical function: glycosyltransferase activity
Biological process: response to sorbitol
Cellular component: plasmodesma

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EC 2.4.1.13: Sucrose synthase

Reaction catalysed:
NDP-glucose + D-fructose = NDP + sucrose
Systematic name:
NDP-alpha-D-glucose:D-fructose 2-alpha-D-glucosyltransferase (configuration-retaining)
Alternative Name(s):
  • NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase
  • Sucrose synthetase
  • Sucrose-UDP glucosyltransferase
  • Sucrose-uridine diphosphate glucosyltransferase
  • UDP-glucose-fructose glucosyltransferase
  • UDPglucose-fructose glucosyltransferase
  • Uridine diphosphoglucose-fructose glucosyltransferase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00534
Domain description: Glycosyl transferases group 1
Occurring in:
  1. Sucrose synthase 1
The deposited structure of PDB entry 3s29 contains 8 copies of Pfam domain PF00534 (Glycosyl transferases group 1) in Sucrose synthase 1. Showing 1 copy in chain H.

PF00862
Domain description: Sucrose synthase
Occurring in:
  1. Sucrose synthase 1
The deposited structure of PDB entry 3s29 contains 8 copies of Pfam domain PF00862 (Sucrose synthase) in Sucrose synthase 1. Showing 1 copy in chain H.

InterPro InterPro annotations
IPR012820
Domain description: Sucrose synthase, plant/cyanobacteria
Occurring in:
  1. Sucrose synthase 1
IPR001296
Domain description: Glycosyl transferase, family 1
Occurring in:
  1. Sucrose synthase 1
IPR000368
Domain description: Sucrose synthase
Occurring in:
  1. Sucrose synthase 1

Structure domains

CATH CATH domains
3.40.50.2000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: Glycogen Phosphorylase B;
Occurring in:
  1. Sucrose synthase 1
The deposited structure of PDB entry 3s29 contains 16 copies of CATH domain 3.40.50.2000 (Rossmann fold) in Sucrose synthase 1. Showing 2 copies in chain H.
1.20.120.1230
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Occurring in:
  1. Sucrose synthase 1
The deposited structure of PDB entry 3s29 contains 8 copies of CATH domain 1.20.120.1230 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in Sucrose synthase 1. Showing 1 copy in chain H.
3.10.450.330
Class: Alpha Beta
Architecture: Roll
Topology: Nuclear Transport Factor 2; Chain: A,
Homology: Nuclear Transport Factor 2; Chain: A,
Occurring in:
  1. Sucrose synthase 1
The deposited structure of PDB entry 3s29 contains 8 copies of CATH domain 3.10.450.330 (Nuclear Transport Factor 2; Chain: A,) in Sucrose synthase 1. Showing 1 copy in chain H.

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