› 3s8w

X-ray diffraction
2.6Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-546103 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon alpha/beta receptor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 105 amino acids
Theoretical weight: 12.05 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P48551 (Residues: 131-232; Coverage: 21%)
Gene names: IFNABR, IFNAR2, IFNARB
Sequence domains: Interferon-alpha/beta receptor, fibronectin type III
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
1 modified residue:
Ligand MSE 9 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P6522
Unit cell:
a: 82.66Å b: 82.66Å c: 225.33Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.218 0.27
Expression system: Trichoplusia ni

Quick links

Citations

75 review citations

JAK/STAT signaling in hematological malignancies.
Vainchenker et al. (2013)
74 more

2 mentions without citation

Structural linkage between ligand discrimination and receptor activation by type I interferons.
Thomas et al. (2011)
1 more