Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Selective cleavage of Tyr-|-Gly bond in picornavirus polyprotein.
NTP + H(2)O = NDP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
3C protease (preferred)
PDBe Complex ID:
PDB-CPX-122716 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3C protease
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 190 amino acids
Theoretical weight: 21.15 KDa
Source organism: Enterovirus A71
Expression system: Escherichia coli BL21(DE3)
UniProt:
Structure domains: Trypsin-like serine proteases
Length: 190 amino acids
Theoretical weight: 21.15 KDa
Source organism: Enterovirus A71
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
E0WWC7 (Residues: 1548-1731; Coverage: 8%)
Structure domains: Trypsin-like serine proteases
