› 3so8

X-ray diffraction
1.9Å resolution

Crystal Structure of ANKRA

Released:
DOI: 10.2210/pdb3so8/pdb
PDB entry 3so8 coloured by chain, front view.
PDB entry 3so8 coloured by chain, side view.
PDB entry 3so8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Sequence-specific recognition of a PxLPxI/L motif by an ankyrin repeat tumbler lock.
Xu C, Jin J, Bian C, Lam R, Tian R, Weist R, You L, Nie J, Bochkarev A, Tempel W, Tan CS, Wasney GA, Vedadi M, Gish GD, Arrowsmith CH, Pawson T, Yang XJ, Min J
Sci Signal 5 ra39 (2012)
PMID: 22649097

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190700 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ankyrin repeat family A protein 2 Chain: A
Molecule details ›
Chain: A
Length: 162 amino acids
Theoretical weight: 17.67 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H9E1 (Residues: 149-310; Coverage: 52%)
Gene names: ANKRA, ANKRA2
Sequence domains:
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P212121
Unit cell:
a: 39.147Å b: 40.776Å c: 99.061Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.218 0.255
Expression system: Escherichia coli

Quick links

Citations

7 review citations

The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy.
Li et al. (2020)
6 more

5 mentions without citation

Poxviral ANKR/F-box Proteins: Substrate Adapters for Ubiquitylation and More.
Ingham et al. (2022)
4 more