EC 1.5.1.3: Dihydrofolate reductase
Reaction catalysed:
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH
Systematic name:
5,6,7,8-tetrahydrofolate:NADP(+) oxidoreductase
Alternative Name(s):
- 7,8-dihydrofolate reductase
- DHFR
- Dihydrofolate reductase:thymidylate synthase
- Dihydrofolic acid reductase
- Dihydrofolic reductase
- Folic acid reductase
- Folic reductase
- NADPH-dihydrofolate reductase
- Pteridine reductase:dihydrofolate reductase
- Tetrahydrofolate dehydrogenase
- Thymidylate synthetase-dihydrofolate reductase
Protein family (Pfam)![The deposited structure of PDB entry 3srq contains 1 copy of Pfam domain PF00186 (Dihydrofolate reductase) in Dihydrofolate reductase. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/3srq_1_X_Pfam_PF00186_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3srq</span> contains 1 copy of Pfam domain <span class='highlight'>PF00186 (Dihydrofolate reductase)</span> in <span class='highlight'>Dihydrofolate reductase</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")
InterPro annotations
CATH domain![The deposited structure of PDB entry 3srq contains 1 copy of CATH domain 3.40.430.10 (Dihydrofolate Reductase, subunit A) in Dihydrofolate reductase. Showing 1 copy in chain A [auth X].](https://www.ebi.ac.uk/pdbe/static/entry/3srq_1_X_CATH_3.40.430.10_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>3srq</span> contains 1 copy of CATH domain <span class='highlight'>3.40.430.10 (Dihydrofolate Reductase, subunit A)</span> in <span class='highlight'>Dihydrofolate reductase</span>. Showing 1 copy in chain <span class='highlight'>A [auth X]</span>.")