› 3svf

X-ray diffraction
1.98Å resolution

Crystal Structure of the first bromodomain of human BRD4 in complex with a dihydro-quinazolin ligand

Released:
DOI: 10.2210/pdb3svf/pdb
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PDB entry 3svf coloured by chain, front view.
PDB entry 3svf coloured by chain, side view.
PDB entry 3svf coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Filippakopoulos P, Picaud S, Felletar I, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Knapp S, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130112 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain-containing protein 4 Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60885 (Residues: 44-168; Coverage: 9%)
Gene names: BRD4, HUNK1
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand WDR 1 x WDR
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P212121
Unit cell:
a: 43.56Å b: 48.98Å c: 60.28Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.226
Expression system: Escherichia coli

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