› › Function and Biology

A Novel High Affinity Integrin alphaIIbbeta3 Receptor Antagonist That Unexpectedly Displaces Mg2+ from the beta3 MIDAS

Source organisms:
Biochemical function: not assigned
Biological process: cell adhesion
Cellular component: integrin complex

Quick links

GO terms

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Sequence families

Pfam Protein families (Pfam)
PF01839
Domain description: FG-GAP repeat
Occurring in:
  1. Integrin alpha-IIb heavy chain
The deposited structure of PDB entry 3t3p contains 4 copies of Pfam domain PF01839 (FG-GAP repeat) in Integrin alpha-IIb heavy chain. Showing 2 copies in chain A.

PF18372
Domain description: Integrin beta epidermal growth factor like domain 1
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3t3p contains 2 copies of Pfam domain PF18372 (Integrin beta epidermal growth factor like domain 1) in Integrin beta-3. Showing 1 copy in chain D.

PF00362
Domain description: Integrin beta chain VWA domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3t3p contains 2 copies of Pfam domain PF00362 (Integrin beta chain VWA domain) in Integrin beta-3. Showing 1 copy in chain D.

PF17205
Domain description: Integrin plexin domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3t3p contains 2 copies of Pfam domain PF17205 (Integrin plexin domain) in Integrin beta-3. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR015812
Domain description: Integrin beta subunit
Occurring in:
  1. Integrin beta-3
IPR013519
Domain description: Integrin alpha beta-propellor
Occurring in:
  1. Integrin alpha-IIb heavy chain
IPR000413
Domain description: Integrin alpha chain
Occurring in:
  1. Integrin alpha-IIb heavy chain
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Monoclonal antibody 10E5 heavy chain
  2. Monoclonal antibody 10E5 light chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Monoclonal antibody 10E5 heavy chain
  2. Monoclonal antibody 10E5 light chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Monoclonal antibody 10E5 heavy chain
  2. Monoclonal antibody 10E5 light chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Monoclonal antibody 10E5 heavy chain
  2. Monoclonal antibody 10E5 light chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Monoclonal antibody 10E5 heavy chain
  2. Monoclonal antibody 10E5 light chain
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. Monoclonal antibody 10E5 heavy chain
  2. Monoclonal antibody 10E5 light chain
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. Integrin beta-3
IPR002369
Domain description: Integrin beta subunit, VWA domain
Occurring in:
  1. Integrin beta-3
IPR013517
Domain description: FG-GAP repeat
Occurring in:
  1. Integrin alpha-IIb heavy chain
IPR028994
Domain description: Integrin alpha, N-terminal
Occurring in:
  1. Integrin alpha-IIb heavy chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. Monoclonal antibody 10E5 light chain
IPR040622
Domain description: Integrin beta, epidermal growth factor-like domain 1
Occurring in:
  1. Integrin beta-3
IPR032695
Domain description: Integrin domain superfamily
Occurring in:
  1. Integrin beta-3
IPR016201
Domain description: PSI domain
Occurring in:
  1. Integrin beta-3
IPR033760
Domain description: Integrin beta N-terminal
Occurring in:
  1. Integrin beta-3

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Monoclonal antibody 10E5 heavy chain
  2. Monoclonal antibody 10E5 light chain
The deposited structure of PDB entry 3t3p contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Monoclonal antibody 10E5 heavy chain. Showing 2 copies in chain G [auth H].
The deposited structure of PDB entry 3t3p contains 4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Monoclonal antibody 10E5 light chain. Showing 2 copies in chain F.
2.60.40.1510
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: ntegrin, alpha v. Chain A, domain 3
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3t3p contains 2 copies of CATH domain 2.60.40.1510 (Immunoglobulin-like) in Integrin beta-3. Showing 1 copy in chain D.
3.40.50.410
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: von Willebrand factor, type A domain
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3t3p contains 2 copies of CATH domain 3.40.50.410 (Rossmann fold) in Integrin beta-3. Showing 1 copy in chain D.
3.30.1680.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: ligand-binding face of the semaphorins, domain 2
Homology: ligand-binding face of the semaphorins, domain 2
Occurring in:
  1. Integrin beta-3
The deposited structure of PDB entry 3t3p contains 2 copies of CATH domain 3.30.1680.10 (ligand-binding face of the semaphorins, domain 2) in Integrin beta-3. Showing 1 copy in chain D.
2.130.10.130
Class: Mainly Beta
Architecture: 7 Propeller
Topology: Methylamine Dehydrogenase; Chain H
Homology: Integrin alpha, N-terminal
Occurring in:
  1. Integrin alpha-IIb heavy chain
The deposited structure of PDB entry 3t3p contains 2 copies of CATH domain 2.130.10.130 (Methylamine Dehydrogenase; Chain H) in Integrin alpha-IIb heavy chain. Showing 1 copy in chain A.

Quick links