Function and Biology

Crystal structure of the human ubiquitin-conjugating enzyme (E2) UbcH5b

Source organism: Homo sapiens
Biochemical function: ubiquitin conjugating enzyme activity
Biological process: protein K48-linked ubiquitination
Cellular component: extracellular exosome

EC 2.3.2.24: (E3-independent) E2 ubiquitin-conjugating enzyme

Reaction catalysed:
(1a) S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [(E3-independent) E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-monoubiquitinyl-[(E3-independent) ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:L-lysine ubiquitinyl transferase ([E3 ubiquitin transferase]-independent)
Alternative Name(s):
  • E2-230K
  • E3-independent ubiquitin-conjugating enzyme E2
  • UBE2O

EC 2.3.2.23: E2 ubiquitin-conjugating enzyme

Reaction catalysed:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Systematic name:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine:[E2 ubiquitin-conjugating enzyme] ubiquitinyl transferase
Alternative Name(s):
  • UBC
  • Ubiquitin-carrier-protein E2
  • Ubiquitin-conjugating enzyme E2

Sequence family

Pfam Protein family (Pfam)
PF00179
Domain description: Ubiquitin-conjugating enzyme
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 D2
The deposited structure of PDB entry 3tgd contains 1 copy of Pfam domain PF00179 (Ubiquitin-conjugating enzyme) in Ubiquitin-conjugating enzyme E2 D2. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000608
Domain description: Ubiquitin-conjugating enzyme E2
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 D2
IPR016135
Domain description: Ubiquitin-conjugating enzyme/RWD-like
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 D2
IPR023313
Domain description: Ubiquitin-conjugating enzyme, active site
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 D2

Structure domain

CATH CATH domain
3.10.110.10
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin Conjugating Enzyme
Homology: Ubiquitin Conjugating Enzyme
Occurring in:
  1. Ubiquitin-conjugating enzyme E2 D2
The deposited structure of PDB entry 3tgd contains 1 copy of CATH domain 3.10.110.10 (Ubiquitin Conjugating Enzyme) in Ubiquitin-conjugating enzyme E2 D2. Showing 1 copy in chain A.