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Crystal structure of Methanothermobacter thermautotrophicus orotidine 5'-monophosphate decarboxylase complexed with 6-amino-UMP

Source organism: Methanothermobacter thermautotrophicus str. Delta H
Biochemical function: carboxy-lyase activity
Biological process: 'de novo' UMP biosynthetic process
Cellular component: cytosol

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EC 4.1.1.23: Orotidine-5'-phosphate decarboxylase

Reaction catalysed:
Orotidine 5'-phosphate = UMP + CO(2)
Systematic name:
Orotidine-5'-phosphate carboxy-lyase (UMP-forming)
Alternative Name(s):
  • ODCase
  • OMP decarboxylase
  • OMP-DC
  • OMPdcase
  • Orotate decarboxylase
  • Orotate monophosphate decarboxylase
  • Orotic decarboxylase
  • Orotidine 5'-phosphate decarboxylase
  • Orotidine monophosphate decarboxylase
  • Orotidine phosphate decarboxylase
  • Orotidine-5'-monophosphate decarboxylase
  • Orotidine-5'-phosphate carboxy-lyase
  • Orotidylic acid decarboxylase
  • Orotidylic decarboxylase
  • Orotodylate decarboxylase
  • UMP synthase
  • Uridine 5'-monophosphate synthase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00215
Domain description: Orotidine 5'-phosphate decarboxylase / HUMPS family
Occurring in:
  1. Orotidine 5'-phosphate decarboxylase
The deposited structure of PDB entry 3thq contains 2 copies of Pfam domain PF00215 (Orotidine 5'-phosphate decarboxylase / HUMPS family) in Orotidine 5'-phosphate decarboxylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001754
Domain description: Orotidine 5'-phosphate decarboxylase domain
Occurring in:
  1. Orotidine 5'-phosphate decarboxylase
IPR014732
Domain description: Orotidine 5'-phosphate decarboxylase
Occurring in:
  1. Orotidine 5'-phosphate decarboxylase
IPR018089
Domain description: Orotidine 5'-phosphate decarboxylase, active site
Occurring in:
  1. Orotidine 5'-phosphate decarboxylase
IPR047595
Domain description: Orotidine 5'-phosphate decarboxylase, archaeal
Occurring in:
  1. Orotidine 5'-phosphate decarboxylase
IPR011060
Domain description: Ribulose-phosphate binding barrel
Occurring in:
  1. Orotidine 5'-phosphate decarboxylase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Orotidine 5'-phosphate decarboxylase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Orotidine 5'-phosphate decarboxylase
The deposited structure of PDB entry 3thq contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Orotidine 5'-phosphate decarboxylase. Showing 1 copy in chain A.

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