› 3trb

X-ray diffraction
2Å resolution

Structure of an addiction module antidote protein of a HigA (higA) family from Coxiella burnetii

Released:
DOI: 10.2210/pdb3trb/pdb
PDB entry 3trb coloured by chain, front view.
PDB entry 3trb coloured by chain, side view.
PDB entry 3trb coloured by chain, top view.
Source organism: Coxiella burnetii
Primary publication:
Structural genomics for drug design against the pathogen Coxiella burnetii.
Franklin MC, Cheung J, Rudolph MJ, Burshteyn F, Cassidy M, Gary E, Hillerich B, Yao ZK, Carlier PR, Totrov M, Love JD
Proteins 83 2124-36 (2015)
PMID: 26033498

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182910 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH cro/C1-type domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 104 amino acids
Theoretical weight: 11.67 KDa
Source organism: Coxiella burnetii
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q83BL4 (Residues: 3-103; Coverage: 98%)
Gene names: CBU_1490, higA
Sequence domains: Helix-turn-helix
Structure domains: lambda repressor-like DNA-binding domains

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P41212
Unit cell:
a: 44.669Å b: 44.669Å c: 221.657Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.243
Expression system: Escherichia coli BL21(DE3)

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Citations

5 review citations

Laccases of prokaryotic origin: enzymes at the interface of protein science and protein technology.
Martins et al. (2015)
4 more

8 mentions without citation

Multiple toxin-antitoxin systems in Mycobacterium tuberculosis.
Sala et al. (2014)
7 more