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Crystal structure of the Sir3 BAH domain in complex with a nucleosome core particle.

Source organisms:
Biochemical function: protein heterodimerization activity
Biological process: heterochromatin formation
Cellular component: chromosome

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF00125
Domain description: Core histone H2A/H2B/H3/H4
Occurring in:
  1. Histone H3.2
  2. Histone H2A type 1
  3. Histone H2B 1.1
The deposited structure of PDB entry 3tu4 contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H3.2. Showing 1 copy in chain A.
The deposited structure of PDB entry 3tu4 contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2A type 1. Showing 1 copy in chain C.
The deposited structure of PDB entry 3tu4 contains 2 copies of Pfam domain PF00125 (Core histone H2A/H2B/H3/H4) in Histone H2B 1.1. Showing 1 copy in chain D.

PF01426
Domain description: BAH domain
Occurring in:
  1. Regulatory protein SIR3
The deposited structure of PDB entry 3tu4 contains 2 copies of Pfam domain PF01426 (BAH domain) in Regulatory protein SIR3. Showing 1 copy in chain K.

PF16211
Domain description: C-terminus of histone H2A
Occurring in:
  1. Histone H2A type 1
The deposited structure of PDB entry 3tu4 contains 2 copies of Pfam domain PF16211 (C-terminus of histone H2A) in Histone H2A type 1. Showing 1 copy in chain C.

PF15511
Domain description: Centromere kinetochore component CENP-T histone fold
Occurring in:
  1. Histone H4
The deposited structure of PDB entry 3tu4 contains 2 copies of Pfam domain PF15511 (Centromere kinetochore component CENP-T histone fold) in Histone H4. Showing 1 copy in chain F.

InterPro InterPro annotations
IPR000164
Domain description: Histone H3/CENP-A
Occurring in:
  1. Histone H3.2
IPR000558
Domain description: Histone H2B
Occurring in:
  1. Histone H2B 1.1
IPR002119
Domain description: Histone H2A
Occurring in:
  1. Histone H2A type 1
IPR001951
Domain description: Histone H4
Occurring in:
  1. Histone H4
IPR009072
Domain description: Histone-fold
Occurring in:
  1. Histone H3.2
  2. Histone H4
  3. Histone H2A type 1
  4. Histone H2B 1.1
IPR007125
Domain description: Histone H2A/H2B/H3
Occurring in:
  1. Histone H3.2
  2. Histone H2A type 1
  3. Histone H2B 1.1
IPR001025
Domain description: Bromo adjacent homology (BAH) domain
Occurring in:
  1. Regulatory protein SIR3
IPR043151
Domain description: Bromo adjacent homology (BAH) domain superfamily
Occurring in:
  1. Regulatory protein SIR3
IPR032454
Domain description: Histone H2A, C-terminal domain
Occurring in:
  1. Histone H2A type 1
IPR032458
Domain description: Histone H2A conserved site
Occurring in:
  1. Histone H2A type 1
IPR035425
Domain description: CENP-T/Histone H4, histone fold
Occurring in:
  1. Histone H4
IPR004823
Domain description: TATA box binding protein associated factor (TAF), histone-like fold domain
Occurring in:
  1. Histone H4
IPR019809
Domain description: Histone H4, conserved site
Occurring in:
  1. Histone H4

Structure domains

CATH CATH domains
1.10.20.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Histone, subunit A
Homology: Histone, subunit A
Occurring in:
  1. Histone H3.2
  2. Histone H4
  3. Histone H2A type 1
  4. Histone H2B 1.1
The deposited structure of PDB entry 3tu4 contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H3.2. Showing 1 copy in chain A.
The deposited structure of PDB entry 3tu4 contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H4. Showing 1 copy in chain F.
The deposited structure of PDB entry 3tu4 contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H2A type 1. Showing 1 copy in chain C.
The deposited structure of PDB entry 3tu4 contains 2 copies of CATH domain 1.10.20.10 (Histone, subunit A) in Histone H2B 1.1. Showing 1 copy in chain D.
2.30.30.490
Class: Mainly Beta
Architecture: Roll
Topology: SH3 type barrels.
Homology: SH3 type barrels.
Occurring in:
  1. Regulatory protein SIR3
The deposited structure of PDB entry 3tu4 contains 2 copies of CATH domain 2.30.30.490 (SH3 type barrels.) in Regulatory protein SIR3. Showing 1 copy in chain K.

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