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Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase

Source organism: Homo sapiens
Biochemical function: ubiquitin-protein transferase activity
Biological process: not assigned
Cellular component: not assigned

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EC 2.3.2.26: HECT-type E3 ubiquitin transferase

Reaction catalysed:
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Systematic name:
S-ubiquitinyl-[HECT-type E3-ubiquitin transferase]-L-cysteine:acceptor protein ubiquitin transferase (isopeptide bond-forming)
Alternative Name(s):
  • HECT E3 ligase
  • Ubiquitin transferase HECT-E3

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00632
Domain description: HECT-domain (ubiquitin-transferase)
Occurring in:
  1. E3 ubiquitin-protein ligase Itchy homolog
The deposited structure of PDB entry 3tug contains 1 copy of Pfam domain PF00632 (HECT-domain (ubiquitin-transferase)) in E3 ubiquitin-protein ligase Itchy homolog. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR000569
Domain description: HECT domain
Occurring in:
  1. E3 ubiquitin-protein ligase Itchy homolog
IPR035983
Domain description: HECT, E3 ligase catalytic domain
Occurring in:
  1. E3 ubiquitin-protein ligase Itchy homolog

Structure domains

CATH CATH domains
3.90.1750.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Hect, E3 ligase catalytic domain fold
Homology: Hect, E3 ligase catalytic domains
Occurring in:
  1. E3 ubiquitin-protein ligase Itchy homolog
The deposited structure of PDB entry 3tug contains 1 copy of CATH domain 3.90.1750.10 (Hect, E3 ligase catalytic domain fold) in E3 ubiquitin-protein ligase Itchy homolog. Showing 1 copy in chain A.
3.30.2410.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Hect, E3 ligase catalytic fold
Homology: Hect, E3 ligase catalytic domain
Occurring in:
  1. E3 ubiquitin-protein ligase Itchy homolog
The deposited structure of PDB entry 3tug contains 1 copy of CATH domain 3.30.2410.10 (Hect, E3 ligase catalytic fold) in E3 ubiquitin-protein ligase Itchy homolog. Showing 1 copy in chain A.

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