EC 3.4.24.56: Insulysin
Reaction catalysed:
Degradation of insulin, glucagon and other polypeptides. No action on proteins.
Alternative Name(s):
- IDE
- Insulin protease
- Insulin proteinase
- Insulin-degrading enzyme
- Insulin-degrading neutral proteinase
- Insulin-glucagon protease
- Insulin-specific protease
- Insulinase
- Metalloinsulinase
GO terms
Biochemical function:
- metal ion binding
- protein-containing complex binding
- insulin binding
- protein homodimerization activity
- identical protein binding
- peptide binding
- beta-endorphin binding
- peptide hormone binding
- ATP hydrolysis activity
- hydrolase activity
- zinc ion binding
- metallopeptidase activity
- peptidase activity
- ATP binding
- metalloendopeptidase activity
- endopeptidase activity
- catalytic activity
- amyloid-beta binding
- nucleotide binding
Biological process:
- regulation of aerobic respiration
- insulin catabolic process
- insulin metabolic process
- amyloid-beta clearance by cellular catabolic process
- amyloid-beta clearance
- proteolysis involved in protein catabolic process
- amyloid-beta metabolic process
- negative regulation of proteolysis
- peptide catabolic process
- hormone catabolic process
- insulin receptor recycling
- protein catabolic process
- antigen processing and presentation of endogenous peptide antigen via MHC class I
- ubiquitin recycling
- bradykinin catabolic process
- response to oxidative stress
- proteolysis
Protein families (Pfam)
InterPro annotations
CATH domain