› 3ui4

X-ray diffraction
0.8Å resolution

0.8 A resolution crystal structure of human Parvulin 14

Released:
DOI: 10.2210/pdb3ui4/pdb
PDB entry 3ui4 coloured by chain, front view.
PDB entry 3ui4 coloured by chain, side view.
PDB entry 3ui4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystallographic proof for an extended hydrogen-bonding network in small prolyl isomerases.
Mueller JW, Link NM, Matena A, Hoppstock L, Rüppel A, Bayer P, Blankenfeldt W
J Am Chem Soc 133 20096-9 (2011)
PMID: 22081960

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195093 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 Chain: A
Molecule details ›
Chain: A
Length: 101 amino acids
Theoretical weight: 11.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y237 (Residues: 36-131; Coverage: 73%)
Gene name: PIN4
Sequence domains: PPIC-type PPIASE domain
Structure domains: Chitinase A; domain 3

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 34.043Å b: 46.966Å c: 51.826Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.095 0.095 0.098
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Structure and function of the human parvulins Pin1 and Par14/17.
Matena et al. (2018)
12 other articles

9 mentions without citation

Macromolecular ab initio phasing enforcing secondary and tertiary structure.
Millán et al. (2015)
8 more