EC 3.4.25.1: Proteasome endopeptidase complex
Reaction catalysed:
Cleavage of peptide bonds with very broad specificity.
Alternative Name(s):
- 26S protease
- Alkaline protease
- Ingensin
- Large multicatalytic protease
- Lens neutral proteinase
- MCP
- Macropain
- Multicatalytic endopeptidase complex
- Multicatalytic proteinase
- Multicatalytic proteinase (complex)
- Prosome
- Proteasome
- Proteasome organelle
- Tricorn protease
- Tricorn proteinase
GO terms
Biochemical function:
Biological process:
Cellular component:
Sequence families
Protein families (Pfam)
PF00227
Domain description:
Proteasome subunit
Occurring in:
Occurring in:
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-6
- Proteasome subunit beta type-10
- Proteasome subunit beta type-3
- Proteasome subunit beta type-2
- Proteasome subunit beta type-8
- Proteasome subunit beta type-1
- Proteasome subunit beta type-4
- Proteasome subunit beta type-9
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-2</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-2. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_1_A_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-4</span>. Showing 1 copy in chain <span class='highlight'>P</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-4. Showing 1 copy in chain P.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_2_P_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-7</span>. Showing 1 copy in chain <span class='highlight'>Q</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-7. Showing 1 copy in chain Q.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_3_Q_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-5</span>. Showing 1 copy in chain <span class='highlight'>R</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-5. Showing 1 copy in chain R.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_4_R_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-1</span>. Showing 1 copy in chain <span class='highlight'>S</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-1. Showing 1 copy in chain S.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_5_S_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-3</span>. Showing 1 copy in chain <span class='highlight'>T</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-3. Showing 1 copy in chain T.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_6_T_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit alpha type-6</span>. Showing 1 copy in chain <span class='highlight'>U</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit alpha type-6. Showing 1 copy in chain U.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_7_U_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-10</span>. Showing 1 copy in chain <span class='highlight'>V</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-10. Showing 1 copy in chain V.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_8_V_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-3</span>. Showing 1 copy in chain <span class='highlight'>W</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-3. Showing 1 copy in chain W.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_9_W_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-2</span>. Showing 1 copy in chain <span class='highlight'>J</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-2. Showing 1 copy in chain J.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_10_J_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-8</span>. Showing 1 copy in chain <span class='highlight'>K</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-8. Showing 1 copy in chain K.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_11_K_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-1</span>. Showing 1 copy in chain <span class='highlight'>L</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-1. Showing 1 copy in chain L.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_12_L_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-4</span>. Showing 1 copy in chain <span class='highlight'>M</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-4. Showing 1 copy in chain M.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_13_M_Pfam_PF00227_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of Pfam domain <span class='highlight'>PF00227 (Proteasome subunit)</span> in <span class='highlight'>Proteasome subunit beta type-9</span>. Showing 1 copy in chain <span class='highlight'>N</span>. The deposited structure of PDB entry 3unh contains 2 copies of Pfam domain PF00227 (Proteasome subunit) in Proteasome subunit beta type-9. Showing 1 copy in chain N.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_14_N_Pfam_PF00227_image-200x200.png)
InterPro annotations
IPR029055
Domain description:
Nucleophile aminohydrolases, N-terminal
Occurring in:
Occurring in:
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-6
- Proteasome subunit beta type-10
- Proteasome subunit beta type-3
- Proteasome subunit beta type-2
- Proteasome subunit beta type-8
- Proteasome subunit beta type-1
- Proteasome subunit beta type-4
- Proteasome subunit beta type-9
IPR001353
Domain description:
Proteasome, subunit alpha/beta
Occurring in:
Occurring in:
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-6
- Proteasome subunit beta type-10
- Proteasome subunit beta type-3
- Proteasome subunit beta type-2
- Proteasome subunit beta type-8
- Proteasome subunit beta type-1
- Proteasome subunit beta type-4
- Proteasome subunit beta type-9
Structure domain
CATH domain
3.60.20.10
Class:
Alpha Beta
Architecture:
4-Layer Sandwich
Topology:
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Homology:
Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1
Occurring in:
- Proteasome subunit alpha type-2
- Proteasome subunit alpha type-4
- Proteasome subunit alpha type-7
- Proteasome subunit alpha type-5
- Proteasome subunit alpha type-1
- Proteasome subunit alpha type-3
- Proteasome subunit alpha type-6
- Proteasome subunit beta type-10
- Proteasome subunit beta type-3
- Proteasome subunit beta type-2
- Proteasome subunit beta type-8
- Proteasome subunit beta type-1
- Proteasome subunit beta type-4
- Proteasome subunit beta type-9
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit alpha type-2</span>. Showing 1 copy in chain <span class='highlight'>A</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-2. Showing 1 copy in chain A.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_1_A_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit alpha type-4</span>. Showing 1 copy in chain <span class='highlight'>B</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-4. Showing 1 copy in chain B.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_2_B_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit alpha type-7</span>. Showing 1 copy in chain <span class='highlight'>C</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-7. Showing 1 copy in chain C.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_3_C_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit alpha type-5</span>. Showing 1 copy in chain <span class='highlight'>D</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-5. Showing 1 copy in chain D.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_4_D_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit alpha type-1</span>. Showing 1 copy in chain <span class='highlight'>E</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-1. Showing 1 copy in chain E.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_5_E_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit alpha type-3</span>. Showing 1 copy in chain <span class='highlight'>F</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-3. Showing 1 copy in chain F.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_6_F_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit alpha type-6</span>. Showing 1 copy in chain <span class='highlight'>G</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit alpha type-6. Showing 1 copy in chain G.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_7_G_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit beta type-10</span>. Showing 1 copy in chain <span class='highlight'>H</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-10. Showing 1 copy in chain H.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_8_H_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit beta type-3</span>. Showing 1 copy in chain <span class='highlight'>I</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-3. Showing 1 copy in chain I.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_9_I_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit beta type-2</span>. Showing 1 copy in chain <span class='highlight'>J</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-2. Showing 1 copy in chain J.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_10_J_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit beta type-8</span>. Showing 1 copy in chain <span class='highlight'>K</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-8. Showing 1 copy in chain K.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_11_K_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit beta type-1</span>. Showing 1 copy in chain <span class='highlight'>L</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-1. Showing 1 copy in chain L.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_12_L_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit beta type-4</span>. Showing 1 copy in chain <span class='highlight'>M</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-4. Showing 1 copy in chain M.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_13_M_CATH_3.60.20.10_image-200x200.png)
![The deposited structure of PDB entry <span class='highlight'>3unh</span> contains 2 copies of CATH domain <span class='highlight'>3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1)</span> in <span class='highlight'>Proteasome subunit beta type-9</span>. Showing 1 copy in chain <span class='highlight'>N</span>. The deposited structure of PDB entry 3unh contains 2 copies of CATH domain 3.60.20.10 (Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1) in Proteasome subunit beta type-9. Showing 1 copy in chain N.](https://www.ebi.ac.uk/pdbe/static/entry/3unh_14_N_CATH_3.60.20.10_image-200x200.png)