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1.5 Angstrom Resolution Crystal Structure of Transaldolase from Francisella tularensis in Covalent Complex with Arabinose-5-Phosphate

Source organism: Francisella tularensis subsp. tularensis
Biochemical function: transferase activity
Biological process: pentose-phosphate shunt, non-oxidative branch
Cellular component: cytoplasm

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EC 2.2.1.2: Transaldolase

Reaction catalysed:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate
Systematic name:
Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase
Alternative Name(s):
  • Dihydroxyacetone synthase
  • Dihydroxyacetone transferase
  • Dihydroxyacetonetransferase
  • Formaldehyde transketolase
  • Glycerone transferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00923
Domain description: Transaldolase/Fructose-6-phosphate aldolase
Occurring in:
  1. Transaldolase
The deposited structure of PDB entry 3upb contains 2 copies of Pfam domain PF00923 (Transaldolase/Fructose-6-phosphate aldolase) in Transaldolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR018225
Domain description: Transaldolase, active site
Occurring in:
  1. Transaldolase
IPR004730
Domain description: Transaldolase type 1
Occurring in:
  1. Transaldolase
IPR001585
Domain description: Transaldolase/Fructose-6-phosphate aldolase
Occurring in:
  1. Transaldolase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. Transaldolase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. Transaldolase
The deposited structure of PDB entry 3upb contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in Transaldolase. Showing 1 copy in chain A.

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