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Crystal structure of BACE1 with its inhibitor

Source organism: Homo sapiens
Biochemical function: aspartic-type endopeptidase activity
Biological process: proteolysis
Cellular component: membrane

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EC 3.4.23.46: Memapsin 2

Reaction catalysed:
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
Systematic name:
-
Alternative Name(s):
  • BACE1
  • Beta-secretase
  • Beta-site APP-cleaving enzyme 1
  • Beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1
  • Beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 (BACE1)
  • Membrane-associated aspartic protease 2

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00026
Domain description: Eukaryotic aspartyl protease
Occurring in:
  1. Beta-secretase 1
The deposited structure of PDB entry 3uqx contains 1 copy of Pfam domain PF00026 (Eukaryotic aspartyl protease) in Beta-secretase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR009119
Domain description: Beta-secretase BACE
Occurring in:
  1. Beta-secretase 1
IPR009120
Domain description: Beta-secretase BACE1
Occurring in:
  1. Beta-secretase 1
IPR001461
Domain description: Aspartic peptidase A1
Occurring in:
  1. Beta-secretase 1
IPR021109
Domain description: Aspartic peptidase domain superfamily
Occurring in:
  1. Beta-secretase 1
IPR001969
Domain description: Aspartic peptidase, active site
Occurring in:
  1. Beta-secretase 1
IPR033121
Domain description: Peptidase family A1 domain
Occurring in:
  1. Beta-secretase 1
IPR033874
Domain description: Memapsin-like
Occurring in:
  1. Beta-secretase 1
IPR043519
Domain description: Nucleotidyltransferase superfamily
Occurring in:
  1. Beta-secretase 1

Structure domain

CATH CATH domain
2.40.70.10
Class: Mainly Beta
Architecture: Beta Barrel
Topology: Cathepsin D, subunit A; domain 1
Homology: Acid Proteases
Occurring in:
  1. Beta-secretase 1
The deposited structure of PDB entry 3uqx contains 2 copies of CATH domain 2.40.70.10 (Cathepsin D, subunit A; domain 1) in Beta-secretase 1. Showing 2 copies in chain A.

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