› 3us9

X-ray diffraction
2.68Å resolution

Crystal Structure of the NCX1 Intracellular Tandem Calcium Binding Domains(CBD12)

Released:
DOI: 10.2210/pdb3us9/pdb
Model geometry
Fit model/data
PDB entry 3us9 coloured by chain, front view.
PDB entry 3us9 coloured by chain, side view.
PDB entry 3us9 coloured by chain, top view.
Source organism: Canis lupus familiaris
Primary publication:
A common Ca2+-driven interdomain module governs eukaryotic NCX regulation.
Giladi M, Sasson Y, Fang X, Hiller R, Buki T, Wang YX, Hirsch JA, Khananshvili D
OpenAccess logo PLoS One 7 e39985 (2012)
PMID: 22768191

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150039 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/calcium exchanger 1 Chain: A
Molecule details ›
Chain: A
Length: 295 amino acids
Theoretical weight: 32.98 KDa
Source organism: Canis lupus familiaris
Expression system: Escherichia coli
UniProt:
  • Canonical: P23685 (Residues: 403-724; Coverage: 31%)
Gene names: NCX1, SLC8A1
Sequence domains: Calx-beta domain
Structure domains: Immunoglobulin-like

Ligands and Environments

1 bound ligand:
Ligand CA 3 x CA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID29
Spacegroup: C2221
Unit cell:
a: 80.67Å b: 152.55Å c: 79.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.234 0.274
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The SLC8 gene family of sodium-calcium exchangers (NCX) - structure, function, and regulation in health and disease.
Khananshvili D. (2013)
3 more

8 mentions without citation

Structural Features of Ion Transport and Allosteric Regulation in Sodium-Calcium Exchanger (NCX) Proteins.
Giladi et al. (2016)
7 more