› 3uv0

X-ray diffraction
1.9Å resolution

Crystal structure of the drosophila MU2 FHA domain

Released:
DOI: 10.2210/pdb3uv0/pdb
PDB entry 3uv0 coloured by chain, front view.
PDB entry 3uv0 coloured by chain, side view.
PDB entry 3uv0 coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1.
Luo S, Ye K
FEBS Lett 586 344-9 (2012)
PMID: 22273583

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194329 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mutator 2, isoform B Chains: A, B
Molecule details ›
Chains: A, B
Length: 102 amino acids
Theoretical weight: 11.06 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9W061 (Residues: 1-101; Coverage: 8%)
Gene names: CG1960, Dmel\CG1960, Dmel_CG1960, MDC1, MU2, Mdc1, Mu2, cDNA D, mu-2, mu2, mutator[2]
Sequence domains: Mutator 2 Fork head associated domain
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P65
Unit cell:
a: 99.86Å b: 99.86Å c: 38.31Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.178 0.227
Expression system: Escherichia coli

Quick links

Citations

1 review citation

FHA domains: Phosphopeptide binding and beyond.
Almawi et al. (2017)

2 mentions without citation

Self-association of a highly charged arginine-rich cell-penetrating peptide.
Tesei et al. (2017)
1 more