› 3v7m

X-ray diffraction
2.02Å resolution

Crystal structure of monoclonal human anti-Rhesus D Fc IgG1 T125(YB2/0) in the presence of Zn2+

Released:
DOI: 10.2210/pdb3v7m/pdb
PDB entry 3v7m coloured by chain, front view.
PDB entry 3v7m coloured by chain, side view.
PDB entry 3v7m coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Effect of zinc on human IgG1 and its FcγR interactions.
Sibéril S, Ménez R, Jorieux S, de Romeuf C, Bourel D, Fridman WH, Ducancel F, Stura EA, Teillaud JL
Immunol Lett 143 60-9 (2012)
PMID: 22553781

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 1 Chain: A
Molecule details ›
Chain: A
Length: 209 amino acids
Theoretical weight: 23.69 KDa
Source organism: Homo sapiens
Expression system: Rattus norvegicus
UniProt:
  • Canonical: P01857 (Residues: 119-327; Coverage: 52%)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, MAN, GAL
Carbohydrate polymer
3 bound ligands:
Ligand ZN 3 x ZN
Ligand IMD 3 x IMD
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2221
Unit cell:
a: 50.22Å b: 147.75Å c: 75.54Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.234 0.286
Expression system: Rattus norvegicus

Quick links

Citations

1 review citation

Molecular engineering of antibodies for therapeutic and diagnostic purposes.
Ducancel et al. (2012)
7 other articles

2 mentions without citation

A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G1.
De Nardis et al. (2017)
1 more