› 3vdk

X-ray diffraction
1.85Å resolution

Crystal structure of circumsporozoite protein aTSR domain, R32 platinum-bound form

Released:
DOI: 10.2210/pdb3vdk/pdb
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Source organism: Plasmodium falciparum 3D7
Primary publication:
Unexpected fold in the circumsporozoite protein target of malaria vaccines.
Doud MB, Koksal AC, Mi LZ, Song G, Lu C, Springer TA
Proc Natl Acad Sci U S A 109 7817-22 (2012)
PMID: 22547819

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-181562 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Circumsporozoite protein Chain: A
Molecule details ›
Chain: A
Length: 77 amino acids
Theoretical weight: 8.9 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: Q7K740 (Residues: 310-374; Coverage: 17%)
Gene names: CSP, PF3D7_0304600
Sequence domains: Thrombospondin type 1 domain
Structure domains: Thrombospondin type-1 (TSP1) repeat

Ligands and Environments

1 bound ligand:
Ligand PT 1 x PT
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: R32
Unit cell:
a: 66.534Å b: 66.534Å c: 86.488Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.176 0.217
Expression system: Komagataella phaffii GS115

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Citations

14 review citations

Antibodies against Plasmodium falciparum malaria at the molecular level.
Julien et al. (2019)
13 more

3 mentions without citation

Plasmodium falciparum pre-erythrocytic stage vaccine development.
Molina-Franky et al. (2020)
2 more

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