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Crystal structure of glycosyltrehalose trehalohydrolase (D252S)

Source organism: Saccharolobus solfataricus
Biochemical function: 4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase activity
Biological process: trehalose biosynthetic process
Cellular component: cytoplasm

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EC 3.2.1.141: 4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase

Reaction catalysed:
Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan
Systematic name:
4-alpha-D-((1->4)-alpha-D-glucano)trehalose glucanohydrolase (trehalose-producing)
Alternative Name(s):
  • Malto-oligosyltrehalose trehalohydrolase
  • Maltooligosyl trehalose trehalohydrolase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00128
Domain description: Alpha amylase, catalytic domain
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
The deposited structure of PDB entry 3vge contains 2 copies of Pfam domain PF00128 (Alpha amylase, catalytic domain) in Malto-oligosyltrehalose trehalohydrolase. Showing 2 copies in chain A.

PF09071
Domain description: Alpha-amylase, C terminal
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
The deposited structure of PDB entry 3vge contains 1 copy of Pfam domain PF09071 (Alpha-amylase, C terminal) in Malto-oligosyltrehalose trehalohydrolase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006047
Domain description: Glycosyl hydrolase, family 13, catalytic domain
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
IPR012768
Domain description: Malto-oligosyltrehalose trehalohydrolase
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
IPR015156
Domain description: Malto-oligosyltrehalose trehalohydrolase, archaeal, C-terminal
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
IPR044901
Domain description: Malto-oligosyltrehalose trehalohydrolase, E-set domain superfamily
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase

Structure domains

CATH CATH domains
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
The deposited structure of PDB entry 3vge contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in Malto-oligosyltrehalose trehalohydrolase. Showing 1 copy in chain A.
2.60.40.1180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Golgi alpha-mannosidase II
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
The deposited structure of PDB entry 3vge contains 1 copy of CATH domain 2.60.40.1180 (Immunoglobulin-like) in Malto-oligosyltrehalose trehalohydrolase. Showing 1 copy in chain A.
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Malto-oligosyltrehalose trehalohydrolase
The deposited structure of PDB entry 3vge contains 1 copy of CATH domain 2.60.40.10 (Immunoglobulin-like) in Malto-oligosyltrehalose trehalohydrolase. Showing 1 copy in chain A.

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