Function and Biology

Structure of an Alpha-Amylase from Malbranchea cinnamomea

Source organism: Malbranchea cinnamomea
Biochemical function: calcium ion binding
Biological process: carbohydrate catabolic process
Cellular component: not assigned

EC 3.2.1.1: Alpha-amylase

Reaction catalysed:
Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units
Systematic name:
4-alpha-D-glucan glucanohydrolase
Alternative Name(s):
  • 1,4-alpha-D-glucan glucanohydrolase
  • Alpha amylase
  • Alpha-amylase
  • Endoamylase
  • Glycogenase
  • Taka-amylase A

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF09260
Domain description: Alpha-amylase, domain C
Occurring in:
  1. alpha-amylase
The deposited structure of PDB entry 3vm7 contains 1 copy of Pfam domain PF09260 (Alpha-amylase, domain C) in alpha-amylase. Showing 1 copy in chain A.

PF00128
Domain description: Alpha amylase, catalytic domain
Occurring in:
  1. alpha-amylase
The deposited structure of PDB entry 3vm7 contains 1 copy of Pfam domain PF00128 (Alpha amylase, catalytic domain) in alpha-amylase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR006047
Domain description: Glycosyl hydrolase, family 13, catalytic domain
Occurring in:
  1. alpha-amylase
IPR015340
Domain description: Alpha-amylase, domain C
Occurring in:
  1. alpha-amylase
IPR013780
Domain description: Glycosyl hydrolase, all-beta
Occurring in:
  1. alpha-amylase
IPR017853
Domain description: Glycoside hydrolase superfamily
Occurring in:
  1. alpha-amylase
IPR013777
Domain description: Alpha-amylase-like
Occurring in:
  1. alpha-amylase

Structure domains

CATH CATH domains
2.60.40.1180
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Golgi alpha-mannosidase II
Occurring in:
  1. alpha-amylase
The deposited structure of PDB entry 3vm7 contains 1 copy of CATH domain 2.60.40.1180 (Immunoglobulin-like) in alpha-amylase. Showing 1 copy in chain A.
3.20.20.80
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Glycosidases
Occurring in:
  1. alpha-amylase
The deposited structure of PDB entry 3vm7 contains 1 copy of CATH domain 3.20.20.80 (TIM Barrel) in alpha-amylase. Showing 1 copy in chain A.