› 3vnf

X-ray diffraction
2.1Å resolution

Structure of the ebolavirus protein VP24 from Sudan

Released:
DOI: 10.2210/pdb3vnf/pdb
PDB entry 3vnf coloured by chain, front view.
PDB entry 3vnf coloured by chain, side view.
PDB entry 3vnf coloured by chain, top view.
Source organism: Sudan ebolavirus
Primary publication:
The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.
Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL, Saphire EO
OpenAccess logo PLoS Pathog 8 e1002550 (2012)
PMID: 22383882

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-178512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Membrane-associated protein VP24 Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 24.58 KDa
Source organism: Sudan ebolavirus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5XX02 (Residues: 13-228; Coverage: 86%)
Gene name: VP24
Sequence domains: Filovirus membrane-associated protein VP24

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 61.11Å b: 61.11Å c: 126.82Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.234 0.27
Expression system: Escherichia coli

Quick links

Citations

33 review citations

Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses.
Martines et al. (2015)
32 more

4 mentions without citation

Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus.
Messaoudi et al. (2015)
3 more