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Structural characterization of Glutamic Acid Decarboxylase; insights into the mechanism of autoinactivation

Source organism: Homo sapiens
Biochemical function: pyridoxal phosphate binding
Biological process: carboxylic acid metabolic process
Cellular component: not assigned

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EC 4.1.1.15: Glutamate decarboxylase

Reaction catalysed:
L-glutamate = 4-aminobutanoate + CO(2)
Systematic name:
L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)
Alternative Name(s):
  • Aspartate 1-decarboxylase
  • Aspartic alpha-decarboxylase
  • Cysteic acid decarboxylase
  • Gamma-glutamate decarboxylase
  • L-aspartate-alpha-decarboxylase
  • L-glutamate 1-carboxy-lyase
  • L-glutamate alpha-decarboxylase
  • L-glutamic acid decarboxylase
  • L-glutamic decarboxylase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00282
Domain description: Pyridoxal-dependent decarboxylase conserved domain
Occurring in:
  1. Glutamate decarboxylase 1
The deposited structure of PDB entry 3vp6 contains 2 copies of Pfam domain PF00282 (Pyridoxal-dependent decarboxylase conserved domain) in Glutamate decarboxylase 1. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR021115
Domain description: Pyridoxal-phosphate binding site
Occurring in:
  1. Glutamate decarboxylase 1
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Glutamate decarboxylase 1
IPR002129
Domain description: Pyridoxal phosphate-dependent decarboxylase
Occurring in:
  1. Glutamate decarboxylase 1
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Glutamate decarboxylase 1

Structure domains

CATH CATH domains
3.90.1150.170
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Glutamate decarboxylase 1
The deposited structure of PDB entry 3vp6 contains 2 copies of CATH domain 3.90.1150.170 (Aspartate Aminotransferase, domain 1) in Glutamate decarboxylase 1. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Glutamate decarboxylase 1
The deposited structure of PDB entry 3vp6 contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Glutamate decarboxylase 1. Showing 1 copy in chain A.

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